There is one thing that absolutely drives me crazy in Python and that is the fact that you can access a variable that was defined outside of a function from within the function without passing it as an argument. I'm not going to lie, that does come in handy at times - especially when you are working with APIs; but it is still a terrible way to do things.
I like the way scoping is done in C++ - each variable is only valid within the block in which it is declared, but obviously that doesn't work in Python since we don't declare variables. Even so, I think that the only variables that should be available in a function are the ones which are created in it or passed to it as arguments. While we can't modify variables that were declared outside of a function in Python, only access them, if the variable is an object you can modify it using it's methods. So if we have a list and we append to it in a function using list.append() it will actually modify the list, which is crazy.
Being able to access variables that were declared outside of the function makes it easy to write bugs and makes it hard to find them. There have been several times when I have declared a variable outside of a function and then I pass it in to the function with a different name and then use the external variable instead of the one passed into the function. The code will work, but not as expected, and it is difficult to track things like this down.
This makes me see much of the merit in functional programming languages like Scala.